Hungering Souls (Global DoT damage increase) + Transplant (Multiple Explosions on Arrival + %Healing on Pools of Blood w/Bone Armor) + Life Drain (Dark Shackles to cast + 100% damage increase but costs life) + Aura of Decay (Mark of Death and Soul Feast on hit) + Wandering Souls (Lots of Poison to synergize with other poison affects from other skills)
Of course you will need to generate lots of ward, 100% glancing blow, crit avoidance, stun avoidance, health leech and protectons/armor.
You can than pump all your DPS into Spell Damage increase and DoT increase. You won’t need any crit at all to deal loads of damage. Since you only need two types of offensive affixes, pumping up defense should be easy. You don’t really want to build any health either and spam health pots for the protections boost from lich passive tree. Lots of intelligence and health regen to counter the poison stacks on yourself. I’m still trying to improve my gear right now but it’s been a lot of fun to play.
Edit: Replaced Aura of Decay with Reaper form for some durability. Enough DPS and sustain to keep the form up for a while.